Syrup Fypenem 50 Dry Syrup

Introduction

Fypenem 50 Dry Syrup is an oral pediatric antibiotic containing Faropenem Sodium, a broad-spectrum beta-lactam antibiotic from the penem class. Manufactured by Biophargroup, a division of Biophar Lifesciences Pvt. Ltd., it is widely used for treating bacterial infections in children. Its broad-spectrum activity makes it effective against both gram-positive and gram-negative bacteria, making it a valuable choice in pediatric antimicrobial therapy.

This formulation is commonly prescribed for respiratory infections (bronchitis, pneumonia, sinusitis), urinary tract infections (UTIs), skin and soft tissue infections, gastrointestinal infections, and otolaryngological conditions like otitis media. It works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial death.

With high oral bioavailability and a well-tolerated safety profile, Fypenem 50 Dry Syrup ensures effective treatment with minimal side effects. The pleasant-tasting syrup form makes administration easier for children. Medical supervision is necessary to ensure proper dosage and duration, reducing the risk of resistance and ensuring successful treatment.

Composition and Formulation

Active Ingredient: Faropenem Sodium
Strength: 50 mg per 5 ml
Dosage Form: Dry syrup for oral suspension
Packaging: Available in a dry powder form that needs to be reconstituted before use

Pharmacodynamics and Pharmacokinetics

Pharmacodynamics: Faropenem exhibits bactericidal activity by inhibiting bacterial cell wall synthesis. It has a strong affinity for penicillin-binding proteins (PBPs), disrupting bacterial cell wall integrity, and leading to cell lysis and death.

Pharmacokinetics:

Absorption: Well absorbed orally with a bioavailability of approximately 85%.
Distribution: Widely distributed in tissues and fluids.
Metabolism: metabolic in the liver.
Excretion is primarily excreted through the kidneys.

Indications

Fypenem 50 Dry Syrup is indicated for treating various bacterial infections, including:

Respiratory Tract Infections: Bronchitis, pneumonia, sinusitis, pharyngitis, and tonsillitis.
Urinary Tract Infections (UTIs): Cystitis and pyelonephritis.
Skin and Soft Tissue Infections: Cellulitis, impetigo, and abscesses.
Gastrointestinal Infections: infectious diarrhea and enteric fever.
Otolaryngological Infections: Otitis media and bacterial conjunctivitis.

Dosage and Administration

The dosage of Fypenem 50 Dry Syrup is determined based on the child’s age, weight, and severity of infection. The standard dosage recommendations are:

Children (3 months to 12 years): 5 mg/kg body weight, administered every 8 to 12 hours.
Reconstitution Instructions:
- Shake the bottle to loosen the powder.
- Add the prescribed amount of boiled and cooled water.
- Shake well before each use.
- Use the provided measuring cup or spoon for accurate dosing.

Mechanism of Action

Faropenem Sodium, the active component of Fypenem 50 Dry Syrup, acts by inhibiting bacterial cell wall synthesis. It binds to PBPs, preventing the final step of peptidoglycan synthesis, which is essential for bacterial cell wall integrity. This leads to bacterial death and eradication of infection.

Contraindications

Fypenem 50 Dry Syrup should not be used in patients with:

Hypersensitivity to Faropenem or other beta-lactam antibiotics (penicillins, cephalosporins, carbapenems).
Severe renal impairment without dosage adjustments.

Warnings and Precautions

Renal Impairment: Dose adjustment is required in patients with kidney dysfunction.
Liver dysfunction: Use with caution in patients with liver diseases.
Hypersensitivity Reactions: Patients with a history of allergic reactions to beta-lactam antibiotics should avoid this medication.
Pregnancy and Lactation: Use under medical supervision if necessary.

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Drug Interactions

Fypenem 50 Dry Syrup may interact with certain medications, such as:

Probenecid: Increases Faropenem levels by reducing renal clearance.
Other Beta-Lactam Antibiotics: This may lead to additive toxicity.
Oral Anticoagulants (Warfarin): May potentiate anticoagulant effects.

Side Effects

While generally well tolerated, some patients may experience:

Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain)
Rash or skin reactions
Headache or dizziness
Changes in liver enzymes
Allergic reactions (in rare cases)

Storage Instructions

Store in a cool and dry place, away from direct sunlight.
Keep out of reach of children.
After reconstitution, use the syrup within the specified period (usually 7-14 days) and store it in the refrigerator.

Advantages of Fypenem 50 Dry Syrup

Broad-spectrum activity: effective against multiple bacterial strains.
Pediatric-friendly formulation: Pleasant taste for better compliance.
High oral bioavailability: ensures optimal therapeutic effects.
Convenient dosing regimen: reduces the frequency of administration.

Conclusion

Fypenem 50 Dry Syrup, manufactured by Biophargroup (Biophar Lifesciences Pvt. Ltd.), is a highly effective antibiotic for pediatric bacterial infections. With its broad-spectrum activity and convenient dosing, it serves as a reliable choice for treating a range of bacterial infections in children. However, it should always be used under medical supervision to ensure safety and efficacy.

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